Punctate White Matter Abnormality in Moderate-to-Late Preterm Infants.

ABSTRACT:

Objective

Moderate-to-late preterm (MLP) infants contribute to the greatest proportion of preterm children with neurodevelopmental impairments. White matter injury (WMI) is common and predicts adverse outcomes in very preterm (VP) infants. However, little is known about white matter abnormality (WMA) in MLP infants. We investigated the burden and distribution of WMA in MLP infants.

Methods

MLP infants were recruited from a randomized trial on neonatal nutrition and a prospective observational cohort in New Zealand, and underwent brain magnetic resonance imaging (MRI) soon after birth and at term-equivalent age (TEA). WMA was manually segmented using an established method. Total and regional WMA volumes and percentage of WMA to total cerebral volume were calculated. Probabili

SUBMITTER: Kennedy E 

PROVIDER: S-EPMC12278191 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature