Hybrid Aptamer Molecularly Imprinted Polymer Nanoparticles for Reducing Oxidized Low-Density Lipoprotein Internalization by Macrophages.

ABSTRACT: Oxidized low-density lipoprotein (oxLDL) is the most typical physiological trigger for the formation of macrophage foam cells, leading to atherosclerosis and coronary heart disease. The inhibition of internalized oxLDL in macrophages is a proven effective strategy for the prevention of atherosclerosis. A hybrid aptamer-molecularly imprinted polymer nanoparticle (AP-MIP NP) is a novel synthetic, biocompatible, selective material that can bind directly to oxLDL and decrease its uptake by macrophages by 62 ± 2% compared to oxLDL alone at a concentration of 8.25 × 10⁷ particles/mL. Oil red O staining indicates that macrophages treated with a combination of AP-MIP NP and oxLDL exhibited a marked decrease in intracellular lipid accumulation compared to those treated with oxLDL alone,

SUBMITTER: Chunta S 

PROVIDER: S-EPMC12278217 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature