The Ethiopian Third National Tuberculosis Drug Resistance Survey Incorporating Whole Genome Sequencing.

ABSTRACT:

Background

Drug-resistant tuberculosis (DR-TB) is a major challenge hindering global tuberculosis control. Ethiopia conducted a third national antituberculosis (TB) drug resistance survey, and this is the first survey to report on drug resistance using whole genome sequencing (WGS) in addition to genotypic and phenotypic test results. The aim of this study was to obtain up-to-date information regarding the magnitude and pattern of drug resistance in Ethiopia.

Methods

A nationwide cross-sectional study was conducted in 217 health facilities across all Ethiopian regional states from August 2017 to January 2019. Sputum specimens were collected from patients with bacteriologically confirmed pulmonary TB to detect resistance to anti-TB drugs with Xpert MTB/RIF assay, culture-base

SUBMITTER: Moga S 

PROVIDER: S-EPMC12278268 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature