Synthesis of Nucleoside Derivatives by Biomimetic Ester Migration.

ABSTRACT: Modified nucleosides play important roles as agents in medicinal chemistry due to their anti-inflammatory, antiviral, and antiproliferative properties, as well as in biochemical processes like protein biosynthesis. Aminoacylated nucleosides in tRNA represent the central transfer unit of amino acids in the biosynthesis of peptides. Consequently, their synthesis in a prebiotic context is of great significance for further elucidations regarding the origin of life. To verify the formation of these structures in complex mixtures of regio- and stereoisomers, reference structures and their synthesis are of fundamental importance. However, state-of-the-art methodologies for the synthesis of monomeric tRNA nucleoside derivatives frequently result in the production of regioisomeric mixtures or encou

SUBMITTER: Kurrle NJ 

PROVIDER: S-EPMC12278338 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature