Red-emitting fluorescent probes based on sulfur-substituted barbituric acid derivatives: synthesis, properties and biomedical applications.

ABSTRACT: Fluorescence bioimaging has emerged as a vital tool for tracking dynamic biochemical processes and monitoring disease biomarkers in vivo. This technique has demonstrated significant clinical and commercial potential in fluorescence-guided surgery (FGS) for tumor treatment, attributed to its real-time visualization capabilities and high biocompatibility. To achieve precise delineation of tumor boundaries and complete tumor resection, the rational design and selection of contrast agents are critical. Herein, we report a novel red-emitting fluorophore, TTS, based on thiobarbituric acid (TBA) derivatives and tetraphenylethylene. The design strategy, synthetic route, optical properties, and cytotoxicity of TTS are systematically described. Benefiting from its highly twisted molecular con

SUBMITTER: Feng X 

PROVIDER: S-EPMC12278382 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature