MyD88 signalling in B cells and antibody responses during Oropouche virus-induced neurological disease in mice.

ABSTRACT:

Background

Oropouche virus (OROV) is a neglected insect-borne orthobunyavirus that causes a febrile illness, neurological disease, and pregnancy complications in humans across an endemic area spanning South and Central America. The host factors associated with disease pathogenesis have nonetheless remained obscure, and little is known about the immune determinants of protection against OROV.

Methods

We tracked morbidity, mortality, viral loads, and serum neutralisation in wild-type (WT), Rag1^-/-, CD19-Cre⁺Ifnar^fl, and CD19-Cre⁺MyD88^fl mice and performed immunophenotyping experiments, passive serum transfers, and adoptive cell transfers to determine how early antibody responses and B cell subsets control viral replication

SUBMITTER: Toledo-Teixeira DA 

PROVIDER: S-EPMC12278419 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature