Prognostic and clinicopathological value of dbc1 expression in human cancers: a systematic review and meta-analysis.

ABSTRACT:

Background

DBC1 is a large nuclear protein that is thought to influence the development of several human cancers. However, further research has revealed that the relationship between DBC1 and the prognosis and pathological characteristics of cancer patients is controversial. The aim of this paper is to explore the significance of DBC1 in cancer through the method of meta-analysis.

Methods

A systematic search of the PubMed, Web of Science, Embase, CNKI, and Wanfang databases was conducted, resulting in the identification of 25 studies encompassing 4014 patients. The Hazard Ratio (HR) and ratio ratios (RR) were combined using STATA 14.0 software, and 95% confidence intervals (CI) were obtained to assess the association of DBC1 with prognostic and pathologic characteristics of

SUBMITTER: Wang H 

PROVIDER: S-EPMC12278428 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature