Regulation of testosterone synthesis in Leydig cells by ClC-2 chloride channel.

ABSTRACT:

In brief

Leydig cell steroidogenesis is essential for spermatogenesis and male fertility. This research reveals that ClC-2 chloride channels enhance testosterone production via increased expression of steroidogenic genes in Leydig cells.

Abstract

Testicular Leydig cells are the main source of testosterone, which is essential for spermatogenesis and male fertility. Leydig cell steroidogenesis is regulated by chloride channels, the molecular composition of which remains obscure. ClC-2 is a hyperpolarization-activated chloride channel present in virtually all tissues. ClC-2 deficiency is associated with the loss of male germ cells in mice and male azoospermia in humans. However, the functional significance of ClC-2 in Leydig cells is still unclear. Herein, we aimed to test the

SUBMITTER: Fu SJ 

PROVIDER: S-EPMC12278444 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature