The predictive value of hyaluronic acid for the severity and prognosis of COVID-19: a retrospective multicenter cohort study.

ABSTRACT:

Background

The aim of this study was to elucidate the relationship between HA levels and clinical outcomes, including disease severity and prognosis.

Methods

A retrospective multicenter cohort analysis was conducted across three medical centers in China from September 2022 to February 2023. Patients with positive nucleic acid for the novel coronavirus were included in the study. The primary endpoint is 28-day mortality.The severity was assessed by the 'Diagnosis and Treatment Plan for Novel Coronavirus Pneumonia (Trial Version 9)'. Analyses assessed HA correlation with severity (Kendall), predictive value for mortality (logistic regression, ROC, Delong test), and survival differences (KM analysis using a Youden index-derived HA cutoff).

Results

A total of 862 patients

SUBMITTER: Mu G 

PROVIDER: S-EPMC12278463 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature