Gender and age effects on the incidence and severity of chemotherapy-induced neuropathic pain: a propensity score matching analysis.

ABSTRACT:

Objective

To determine whether the clinical phenotype of chemotherapy-induced neuropathic pain (CINP) varies based on the gender and age of patients.

Methods

Retrospective, file-based analysis of cancer patients who received any conventional standard of care chemotherapy and were referred to assess the extent of painful chemotherapy-induced peripheral neurotoxicity (CIPN). A Propensity Score Matching Analysis (PSMA) was conducted to create balanced cohorts; accounting for variables that could impact the incidence and severity of CINP in CIPN patients. A total of 205 males and 295 females were initially included, and after PSMA, 191 patients of each gender were equally matched; totaling 382 patients. These patients were divided according to their age to those aged ≤65 years (

SUBMITTER: Argyriou AA 

PROVIDER: S-EPMC12278531 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature