Scale-dependent interactions enable emergent microrheological stress response of actin-vimentin composites.

ABSTRACT: The mechanical properties of the mammalian cell regulate many cellular functions and are largely dictated by the cytoskeleton, a composite network of protein filaments, including actin, microtubules, and intermediate filaments. Interactions between these distinct filaments give rise to emergent mechanical properties that are difficult to generate synthetically, and recent studies have made great strides in advancing our understanding of the mechanical interplay between actin and microtubule filaments. While intermediate filaments play critical roles in the stress response of cells, their effect on the rheological properties of the composite cytoskeleton remains poorly understood. Here, we use optical tweezers microrheology to measure the linear viscoelastic properties and nonlinear stress

SUBMITTER: Pinchiaroli J 

PROVIDER: S-EPMC12278532 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature