Impact of systemic immune inflammation index and systemic inflammation response index on all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome.

ABSTRACT:

Background

The cardiovascular-kidney-metabolic (CKM) syndrome is a systemic condition defined by multifaceted interactions among metabolic risk factors, chronic kidney disorder, and cardiovascular diseases. Inflammation is essential in the pathogenesis and progression of CKM syndrome. Inflammatory markers, including the systemic immune inflammation index (SII) and the systemic inflammation response index (SIRI), function as composite indicators for assessing immune-related inflammatory status. This study seeks to address the associations between SII/SIRI and death outcomes in individuals with CKM syndrome using outcomes from the National Health and Nutrition Examination Survey (NHANES, 1999-2018).

Methods

This cross-sectional investigation comprised 18,452 individuals (≥ 20 

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12278538 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature