Esketamine mitigates endotoxin-induced acute lung injury by suppressing caspase-11-driven pyroptosis.

ABSTRACT:

Background

Acute lung injury (ALI) is a common complication of endotoxemia, which carries a high risk of morbidity and mortality. Currently, no effective drugs exist to treat endotoxin-induced ALI. This study evaluated esketamine's protective effects against endotoxin-induced ALI and explored its underlying mechanisms.

Methods

Cecal ligation and puncture (CLP) was used to create a rat model of endotoxin-induced ALI. Esketamine (10 mg/kg) was injected into the tail vein of rats for drug treatment. The murine sepsis score (MSS) was used to evaluate the state of rats. Hematoxylin and eosin (HE) staining was used to evaluate lung tissue morphology and calculate the lung injury scores. The degree of lung tissue edema was assessed using the wet-to-dry weight (W/D) ratio. The expre

SUBMITTER: Bao Y 

PROVIDER: S-EPMC12278550 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature