Circulating miRNAs correlate with clinical evaluation of activity in ANCA-associated glomerulonephritis.

ABSTRACT:

Introduction

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune necrotizing small vessel vasculitis, frequently resulting in severe renal manifestations such as rapidly progressive glomerulonephritis (AAV-GN). Monitoring disease activity and determining ongoing renal involvement remain significant clinical challenges due to the limitations associated with traditional biomarkers. This study focused on the potential of circulating microRNA (miRNA) as supplementary noninvasive biomarkers for disease activity in AAV-GN.

Methods

This prospective follow-up study involved serum samples from 60 patients with biopsy-proven AAV-GN, collected at renal biopsy and at 3-, 6-, 12-, and 24-month intervals post-biopsy. Nine miRNAs (miR-21-3p, miR-30b/d/e-5p, m

SUBMITTER: Bosnjak M 

PROVIDER: S-EPMC12278571 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature