Genome mining reveals the distribution of biosynthetic gene clusters in Alternaria and related fungal taxa within the family Pleosporaceae.

ABSTRACT:

Background

The advancement of whole genome sequencing techniques has led to the development of genome mining strategies that enable high-resolution research into fungal secondary metabolite (SM) biosynthesis. Alternaria species are producers of prominent SMs including virulence factors and mycotoxins that affect phytosanitation, food safety, and the economy. Here, we apply genome mining to identify a total of 6,323 biosynthetic gene clusters (BGCs) from 187 genomes: 123 Alternaria and 64 from seven other closely related genera in the family Pleosporaceae.

Results

An average of 34 BGCs were detected per genome, with 29 on average for Alternaria genomes. The distribution of different BGC classes (e.g. polyketide synthases, non-ribosomal peptide synthetases) across taxa was inv

SUBMITTER: Kim NE 

PROVIDER: S-EPMC12278603 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature