Association of hepatic biomarkers with incident diabetes: a mediation analysis of the triglyceride-glucose index in a large Chinese cohort.

ABSTRACT:

Background

Diabetes disproportionately impacts low- and middle-income populations, exacerbating existing health disparities. The role of hepatic biomarkers, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the ALT/AST ratio, in predicting diabetes onset remains insufficiently elucidated. This research assessed how these biomarkers relate to diabetes risk, as well as assessed the mediating effect of the triglyceride-glucose (TyG) index.

Methods

The secondary analysis utilized data from the Dryad public database, encompassing a cohort of 211,833 Chinese adults aged ≥ 20 years who underwent health examinations between 2010 and 2016. After applying rigorous exclusion criteria, 50,463 participants were included. Cox proportional hazards models were

SUBMITTER: Li B 

PROVIDER: S-EPMC12278604 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature