Association between paramagnetic rim lesions and pulvinar iron depletion in persons with multiple sclerosis.

ABSTRACT:

Background

The deep gray matter (DGM), especially the pulvinar, and the white matter surrounding chronic active lesions have demonstrated depleted iron levels, indicating a possible mechanistic link. However, no studies have investigated the potential relationship between these phenomena.

Objectives

The study aimed to determine whether PRLs were associated with pulvinar iron depletion and, if so, whether this relationship was spatially mediated.

Methods

This retrospective analysis included 139 people with MS (pwMS) and 43 healthy controls (HCs) scanned at 3T MRI at baseline and after 5.4 ± 0.6 years. Pulvinar iron concentrations (cFe) and iron masses (mFe) were estimated from quantitative susceptibility maps and tested for associations with PRLs. A separate cohort of

SUBMITTER: Reeves JA 

PROVIDER: S-EPMC12278663 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature