Genomic Signatures Correlating With Adverse Pathologic Features in Men Eligible for Active Surveillance.

ABSTRACT:

Background

Genomic biomarkers offer opportunities to improve risk stratification for patients with prostate cancer. We performed a transcriptomic profile of active surveillance (AS)-eligible patients who underwent radical prostatectomy (RP) to understand genomic associations with adverse pathologic features (APF) at RP.

Methods

Patients considered AS-eligible (NCCN low-favorable intermediate risk) but proceeded to RP from February 2012 to September 2024 were identified from our prospective institutional database. Outcomes were classified by presence or absence of APF at RP, which was defined as grade group (GG) ≥ 3, pT3b, or pN1 disease. Previously established genomic signatures of interest were compared between the two groups. Scaled multivariable logistic regression was pe

SUBMITTER: Michael J 

PROVIDER: S-EPMC12278701 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature