Comprehensive Genomic Profiling Testing for Castration-Resistant Prostate Cancer in Advanced Elderly Patients: A Single-Center Retrospective Cohort Study.

ABSTRACT:

Background

Prostate cancer (PCa) is the second most common solid tumor in men, and its incidence is strongly dependent on age. With the aging global population, this poses a significant medical and sociodemographic issue. As treatment options for castration-resistant prostate cancer (CRPC) expand, the proportion of elderly patients with CRPC is expected to increase. Comprehensive genomic profiling (CGP) testing is becoming increasingly utilized for PCa; however, evidence on age-related outcomes or benefits is limited. This study aimed to evaluate the efficacy of CGP testing in advanced elderly patients with CRPC compared to younger patients.

Methods

We conducted a single-center, retrospective cohort study at Hiroshima University, including Japanese men aged ≥ 20 years who un

SUBMITTER: Fukushima T 

PROVIDER: S-EPMC12278702 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature