Role of Cell-Cycle Proliferation Test, Triple Hit Phenotype, and TMPRSS2-ERG Expression to Evaluate the Risk of Progression in Prostate Cancer Patients Under Active Surveillance.

ABSTRACT:

Background

An accurate estimation of progression risk in patients with prostate cancer (PCa) amenable to active surveillance (AS) is still an unmet need. Among available biomarkers, we considered Prolaris cell-cycle progression (CCP) test, "triple hit" phenotype (ERG overexpression, PTEN and prostein expression loss) and elevated expression levels of TMPRSS2-ERG gene fusions.

Methods

We performed a case-control study, enrolling patients that entered the AS programme at our tertiary referral Institution. Men subsequently undergoing radical prostatectomy for progression were considered as "cases", while men still on AS at the end of the follow-up period were labeled as "controls". CCP test, triple hit and TMPRSS2-ERG expression analyses were performed on tumoral tissue retriev

SUBMITTER: Oderda M 

PROVIDER: S-EPMC12278703 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature