Downregulation of NONO Suppresses Proliferation, Migration, and Invasion in Metastatic Prostate Cancer.

ABSTRACT:

Background

As prostate cancer (PCa) remains one of the leading causes of cancer-related death in men, it is important to develop effective therapeutic approaches for the treatment of metastatic PCa and to improve the accuracy of prognosis for aggressive tumors. Non-POU domain-containing octamer-binding (NONO) is involved in RNA transport and almost all steps of gene regulation, and aberrant expression is associated with tumorigenesis in various tumor entities.

Methods

Immunohistochemical analysis of the expression of NONO was performed in a cohort of 405 patient samples, including 54 benign prostate tissues, 250 primary prostate tumors, and 101 metastatic tissue samples. To assess the role of NONO in PCa cells, siRNA-mediated knockdown of NONO in the metastatic PCa cell line

SUBMITTER: Lemster AL 

PROVIDER: S-EPMC12278708 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature