Photoactive monofunctional Pt(ii)-cyanine complex for nucleus and mitochondria dual-targeted antitumor therapy.

ABSTRACT: Monofunctional platinum (Pt) complexes, which have single reactive site for binding to DNA, exhibit distinct mechanisms of action compared to those of currently approved Pt-based chemotherapeutic drugs. Although monofunctional Pt complexes offer a promising strategy for overcoming chemotherapeutic resistance and reducing systemic toxicity, their antitumor effect is limited. Herein, we developed a photoactive monofunctional Pt(ii)-cyanine dye complex (denoted as Pt-CDPEN) for cellular nucleus and mitochondria dual-targeted antitumor therapy. Due to the introduction of heavy atom Pt, Pt-CDPEN showed a 2.1-fold higher singlet oxygen quantum yield than that of cyanine dye. The half-maximal inhibitory concentration (IC₅₀) of photoactivated Pt-CDPEN is over 16-fold lower than that of

SUBMITTER: He T 

PROVIDER: S-EPMC12278765 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature