Protein Kinase C promotes peroxisome biogenesis and peroxisome-endoplasmic reticulum interaction.

ABSTRACT: Peroxisomes carry out a diverse set of metabolic functions, including oxidation of very long-chain fatty acids, degradation of D-amino acids and hydrogen peroxide, and bile acid production. Many of these functions are upregulated on demand; therefore, cells control peroxisome abundance, and by extension peroxisome function, in response to environmental and developmental cues. The mechanisms upregulating peroxisomes in mammalian cells have remained unclear. Here, we identify a signaling regulatory network that coordinates cellular demand for peroxisomes and peroxisome abundance by regulating peroxisome proliferation and interaction with ER. We show that PKC promotes peroxisome PEX11b-dependent formation. PKC activation leads to an increase in peroxisome-ER contact site formation through ina

SUBMITTER: Borisyuk A 

PROVIDER: S-EPMC12278821 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature