Catalytic acidic deep eutectic mixture for efficient and promising synthesis of quinazolinone and quinoxaline derivatives.

ABSTRACT: A facilitated and economical protocol was designed to synthesize novel acidic deep eutectic mixture (ADEM) from urea/SbCl₃/HCl as commercially available substrates for the first time. Urea acts as a hydrogen bond donor, SbCl₃ serves as a Lewis acid catalyst, and HCl provides ionic conductivity and an acidic environment. The architectural chemical composition of acidic deep eutectic mixture was confirmed using EDX and FT-IR spectroscopy. This approach led to performing the quinazolinone synthesis with remarkable yield under moderate conditions in a short time and excellent functional group tolerance. Furthermore, in another reaction via a one-pot strategy, π-conjugated polycyclic quinoxaline frameworks were successfully synthesized. Moreover, ADEM demonstrated t

SUBMITTER: Mohammad F 

PROVIDER: S-EPMC12279010 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature