Statins exhibit anti-tumor potential by modulating Wnt/β-catenin signaling in colorectal cancer.

ABSTRACT: Colorectal cancer remains the second leading cause of cancer-related deaths worldwide, highlighting the urgent need for more effective therapies and a deeper understanding of its molecular basis. Drug repurposing has gained traction as a viable strategy to target dysregulated oncogenic pathways. Statins, commonly prescribed for lowering cholesterol, have recently shown potential anti-cancer effects. In this study, we explore how statin treatment influences lipid metabolism, gene expression, and proteomic profiles in colorectal cancer models. Our findings provide direct evidence that statins selectively modulate key components of the Wnt/β-catenin signaling pathway, a major driver of adenoma formation, including members of the special AT-rich sequence-binding (SATB) protein family. We show

SUBMITTER: Tripathi S 

PROVIDER: S-EPMC12279029 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature