SenSet, a novel human lung senescence cell gene signature, identifies cell-specific senescence mechanisms.

ABSTRACT: Cellular senescence is a major hallmark of aging. Senescence is defined as an irreversible growth arrest observed when cells are exposed to a variety of stressors including DNA damage, oxidative stress, or nutrient deprivation. While senescence is a well-established driver of aging and age-related diseases, it is a highly heterogeneous process with significant variations across organisms, tissues, and cell types. The relatively low abundance of senescence in healthy aged tissues represents a major challenge to studying senescence in a given organ, including the human lung. To overcome this limitation, we developed a Positive-Unlabeled (PU) learning framework to generate a comprehensive senescence marker gene list in human lungs (termed SenSet) using the largest publicly available single-ce

SUBMITTER: Hasanaj E 

PROVIDER: S-EPMC12279080 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature