Lard intake results in better hypothalamic leptin responsiveness than beef tallow intake during overnutrition.

ABSTRACT: The hypothalamus helps regulate energy homeostasis, but high-fat diet intake leads to body weight gain and diminishes hypothalamic responses to metabolic hormones such as leptin. The fatty acid compositions of beef tallow and lard, which are representative animal fats in experimental diets, are similar. However, it is not clear how differences in the effects of obesogenic conditions induced by the intake of beef tallow or lard affect hypothalamic leptin responsiveness. Herein, we showed that under obesogenic conditions as 45 kcal% fat, lard-fed mice had lower body weight gain, food intake, respiratory quotient, and adiposity and better glucose balance and insulin sensitivity than beef tallow-fed mice. Furthermore, the central administration of leptin reduced body weight and food intake in

SUBMITTER: Ikeda M 

PROVIDER: S-EPMC12279138 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature