Living Biotherapeutics Using Nanoparticles-Armed Cyanobacteria for Boosting Photodynamic-Immunotherapy of Cancer.

ABSTRACT: The interdisciplinary development of synthetic biology and material sciences propels medicine into a new era. For cancer therapy, living biotherapeutics integrating functional living bacteria with nanomedicine are particularly interesting. The current study developed a living biotherapeutic platform integrating oxygen-self-supplying cyanobacteria with multifunctional prodrug nanoparticles to boost photodynamic immunotherapy. Generally, tetracarboxyl porphyrin is associated with cisplatin via a covalent self-assembly strategy into uniform prodrug-skeletal nanoparticles (ZnNCs). This helped encapsulate the antitumor drug dicumarol derivative (DicTBS). Later, these developed DicTBS-ZnNC nanoparticles helped arm the surface of cyanobacteria using electrostatic adsorption to yield living nanoth

SUBMITTER: Xu Z 

PROVIDER: S-EPMC12279180 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature