Tailored Fluorescent Metal-Organic Frameworks Hybrid Membrane Sensor Arrays: Simultaneous and Selective Quantification of Multiple Antibiotics.

ABSTRACT: Sensor array offers significant potential for rapid, high-throughput antibiotic detection. However, cross-reactivity-based sensor arrays often lack accuracy, despite comprehensive data analysis; while traditional high-affinity-based sensors based on antibodies/aptamers frequently suffer from complicated design and poor robustness. Here, a filterable paper-based fluorescent metal-organic frameworks (MOFs) sensor array is developed for one-to-one recognition and quantification of multiple antibiotics. Three representative MOFs are designed to exceptional affinity and specificity for the target antibiotic. A filtration-assisted detection enhances sensitivity, achieving parts-per-billion (ppb)-level detection in mixed solutions. The proposed approach integrates recognition and signal generatio

SUBMITTER: Ma T 

PROVIDER: S-EPMC12279192 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature