Deciphering the microbiome-metabolome landscape of an inflammatory bowel disease inception cohort.

ABSTRACT: The gut microbiota contribute to the etiopathogenesis of inflammatory bowel disease (IBD), but limitations of prior studies include the use of sequencing alone (restricting exploration of the contribution of microbiota functionality) and the recruitment of patients with well-established disease (introducing potential confounders, such as immunomodulatory medication). Here, we analyze a true IBD inception cohort and healthy controls (HCs) via stool 16S rRNA gene sequencing and multi-system metabolomic phenotyping (using nuclear magnetic spectroscopy and mass spectroscopy), with subsequent integrative network analysis employed to delineate novel microbiota-metabolome interactions in IBD. Marked differences in β diversity and taxonomic profiles were observed both between IBD and HCs, as well

SUBMITTER: Radhakrishnan ST 

PROVIDER: S-EPMC12279270 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature