Contribution of a LysM domain-containing protein regulated by VicRK to <i>Streptococcus sanguinis</i> virulence.

ABSTRACT: Streptococcus sanguinis is a commensal member of the oral microbiome involved in opportunistic cardiovascular infections. In the present study, we investigated the contribution of ssa_0094, a gene strongly regulated by the two-component system VicRK, to functions associated with biofilm formation, immune evasion, and cardiovascular virulence. In silico analysis showed that ssa_0094 encodes a protein with a LysM domain, which is highly conserved among S. sanguinis. Although not an ubiquitous gene, several commensal streptococcal species of the oronasopharynx and zoonotic strains of Streptococcus suis harbor ssa_0094 homologues. A ssa_0094 isogenic mutant (SK0094) showed defects in initiating biofilms on saliva-coated surfaces, reduced

SUBMITTER: Franco EM 

PROVIDER: S-EPMC12279277 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature