Hyponatremia predicts immunotherapy resistance in biliary tract cancer.

ABSTRACT: Hyponatremia, a common electrolyte imbalance in cancer patients, has frequently been disregarded in terms of its prognostic implications for immunotherapy. This study examined the prognostic implications of pre-treatment hyponatremia in patients with biliary tract cancers (BTC) undergoing immunotherapy. We retrospectively included 112 BTC patients who received immune checkpoint inhibitors (ICIs) treatment from August 2016 to December 2024, with an average follow-up period of 11.25 months. In accordance with the diagnosis of hyponatremia before the first ICIs treatment, patients were divided into two distinct groups. There were no significant differences in age (OR = 0.6, 95% CI, 0.2-1.8) or gender distribution (OR = 0.8, 95% CI, 0.3-2.4). Kaplan-Meier curves and the Mantel-Haenszel log-ran

SUBMITTER: Wang T 

PROVIDER: S-EPMC12279278 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature