Improved survival of patients receiving immunotherapy and chemotherapy following curative-intent resection of colorectal liver metastases.

ABSTRACT:

Background

Despite significant advancements in the treatment of patients with colorectal liver metastases (CRLMs), only a minority will experience long-term survival. This study aimed to determine the effect of chemotherapy (CT) and immunotherapy (IT) compared with that of CT alone on patient survival after surgical resection.

Methods

Patients undergoing curative-intent liver resection followed by adjuvant systemic therapy for stage IV colon cancer were identified using the National Cancer Database. Patients were stratified into type of therapy (CT alone vs CT + IT) and microsatellite status. Propensity score-weighted analysis was performed through 1:1 matching based on the nearest neighbor method.

Results

Of 9943 patients who underwent resection of CRLMs, 7971 (80%)

SUBMITTER: Pollini T 

PROVIDER: S-EPMC12279386 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature