Association between preoperative proton pump inhibitor use and postoperative infectious and renal complications following major elective surgery.

ABSTRACT:

Background

Use of poton pump inhibitors (PPIs) is associated with increased risk of Clostridioides difficile-associated colitis, pneumonia, and acute kidney injury. Their effect on postoperative complications is unknown. The objective of this study was to investigate the association between PPIs and the risk of C. difficile-associated colitis, pneumonia, and acute kidney injury following elective surgery.

Methods

In this population-based, matched cohort study, we identified patients who had filled a PPI prescription within 90 days before major elective surgery (2010-2019). Study outcomes included C. difficile-associated colitis, pneumonia, acute kidney injury, gastrointestinal bleeding, and death within 90 days of surgery. We matched patients 1-to-1 on t

SUBMITTER: Dubois L 

PROVIDER: S-EPMC12279390 | biostudies-literature | 2025 Jul-Aug

REPOSITORIES: biostudies-literature