Disease stage-specific atrophy markers in Alzheimer's disease.

ABSTRACT:

Introduction

Structural magnetic resonance imaging (MRI) often lacks diagnostic, prognostic, and monitoring value in Alzheimer's disease (AD), particularly in early disease stages. To improve its utility, we aimed to identify optimal atrophy markers for different intended uses.

Methods

We included 363 older adults; cognitively unimpaired individuals who were negative or positive for amyloid beta (Aβ) and Aβ-positive patients with subjective cognitive decline, mild cognitive impairment, or dementia of the Alzheimer type. MRI and neuropsychological assessments were administered annually for up to 3 years.

Results

Accelerated atrophy of medial temporal lobe subregions was evident already during preclinical AD. Symptomatic disease stages most notably differed in their hip

SUBMITTER: Baumeister H 

PROVIDER: S-EPMC12279471 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature