Comprehensive bioinformatics analysis of malignant transformation and potential therapeutic possibility of lung adenocarcinoma after lipopolysaccharide induction.

ABSTRACT:

Background

Lipopolysaccharides are involved in malignant progression and epithelial-mesenchymal transition of cancer. The mechanism of LPS in malignant progression of lung adenocarcinoma and possible therapeutic strategies need to be explored.

Methods

After obtaining LPS-induced characteristics, 850 samples were characterized. Differences in features were evaluated in different risk subgroups. Cell lines with high scoring performance were selected for in vitro experimental validation and possible potential therapeutic options were identified.

Results

By using bioinformatics analysis to obtain LPS signature genes from the LPS induction cohort, the five intersecting genes were utilized to construct a risk model associated with LPS induction. The high-risk score s

SUBMITTER: Xu W 

PROVIDER: S-EPMC12279497 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature