Differential effects of electroacupuncture and manual acupuncture on spontaneously hypertensive rats: insights from intestinal microbiota and metabolomics.

ABSTRACT:

Background

Hypertension is a significant risk factor for cardiovascular disease, and acupuncture has demonstrated therapeutic effects in managing hypertension. However, the precise antihypertensive mechanisms of acupuncture require further elucidation.

Methods

In this study, 30 male spontaneously hypertensive rats (SHRs) and 10 male Wistar Kyoto (WKY) rats were utilized as experimental models. The SHRs were randomly assigned to three groups: the model group (Group M), the electroacupuncture group (Group EA), and the manual acupuncture group (Group MA), while the WKY rats served as the blank control group. Treatment was given every other day for 8 weeks, and systolic and diastolic blood pressures were measured every 2 weeks during the intervention period. Upon completion of t

SUBMITTER: Liu JP 

PROVIDER: S-EPMC12279516 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature