Bronchopulmonary dysplasia to predict neurodevelopmental impairment in infants born extremely preterm.

ABSTRACT:

Background

Bronchopulmonary dysplasia (BPD) in extremely low gestational age neonates (ELGANs) was associated with neurodevelopmental impairment (NDI). However, the best endpoint of BPD assessment to predict subsequent NDI remains unclear.

Methods

We re-analyzed the PREMILOC trial, previously designed to test the effect of prophylactic hydrocortisone on survival without BPD at 36 weeks of postmenstrual age (BPD_W36) in ELGANs, to compare predictive models of NDI considering baseline characteristics, respiratory course up to and BPD status at 36 or 40 weeks of postmenstrual age (BPD_W36/BPD_W40).

Results

Among 404/519 (77.8%) infants enrolled in the trial alive at 2 years of age, all neurocognitive scores were available for 302 (74.8%) pat

SUBMITTER: Baud O 

PROVIDER: S-EPMC12279537 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature