Gut Microbiota Mediate Periampullary Cancer Through Extracellular Matrix Proteins: A Causal Relationship Study.

ABSTRACT: Recent studies have reported that gut microbiota may play a role in the occurrence and development of digestive system cancers. Periampullary cancer is a relatively rare digestive system cancer which lacks effective targeted therapy and specific drugs. The purpose of this study is to elucidate the relationship between periampullary cancer and gut microbiota. This work collected public genome-wide association study (GWAS) data from 211 gut microbial taxa and three types of cancer related to periampullary cancer, which were used for two-sample Mendelian randomisation (MR) analysis. Based on the analysis of differentially expressed genes between periampullary cancer and adjacent normal tissue, extracellular matrix proteins were selected for further multivariable MR analysis. Finally, the Conn

SUBMITTER: Cheng Z 

PROVIDER: S-EPMC12279554 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature