Global burden of liver cancer attributable to drug use: trends from 1990 to 2021 and projections to 2040.

ABSTRACT:

Background

Liver cancer (LC) is a major global health burden, with hepatocellular carcinoma (HCC) accounting for 75-85% of cases. Drug use, including legal and illicit substances, has emerged as a significant yet underrecognized risk factor for LC, contributing to viral hepatitis transmission, direct hepatotoxicity, and metabolic disorders. This study aims to assess the global and regional trends in drug-induced LC mortality and disease burden from 1990 to 2021 and project future trends up to 2040 using data from the Global Burden of Disease (GBD) 2021 database.

Methods

Utilizing GBD 2021 data, we analyzed age-standardized death rates (ASDR), disability-adjusted life years (DALYs), and estimated annual percentage changes (EAPC) to evaluate trends in drug-induced LC mortality

SUBMITTER: Chen C 

PROVIDER: S-EPMC12279643 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature