Circulating soluble fibroblast activation protein (FAP) in patients with intra-thoracic cancer undergoing chest radiation.

ABSTRACT:

Introduction

Circulating soluble fibroblast activation protein (FAP) is implicated in myocardial infarction, stroke, fibrosis and various cancers. This study investigates changes in FAP concentrations in patients with intra-thoracic malignancies undergoing chest radiation therapy to assess its potential as a biomarker for radiation-induced organ injury.

Methods

Eighteen patients with intra-thoracic cancers (lung, esophagus and metastatic) received chest radiation therapy. Blood samples were taken before and after treatment, and FAP concentrations were measured using an ELISA assay. A control group of 53 healthy volunteers was included for comparison.

Results

Baseline FAP concentrations were significantly lower in cancer patients (median 91 ng/mL, 25th-75th percentiles

SUBMITTER: Lange T 

PROVIDER: S-EPMC12279648 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature