Efficiency of structural brain networks mediates age-associated differences in executive functioning in older adults.

ABSTRACT:

Introduction

Older age is associated with alterations in executive functioning (EF). Age-related alterations in the integrity of structural brain networks may contribute to EF decline, with potential consequences for independent living. Graph theory provides powerful metrics to examine the brain's structural connectome, but few studies have investigated the relationship of EF and structural brain networks, as described by graph-theoretical measures, in older adults. We aimed to investigate the mediatory role of network characteristics for the relationship between age and EF in older adults.

Methods

Eighty-four older adults completed a battery of EF tasks to allow for the extraction of a latent Common-EF factor. White-matter tractograms were generated from diffusion neuroimag

SUBMITTER: Rodriguez-Nieto G 

PROVIDER: S-EPMC12279719 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature