Relationship between serum total bilirubin and frailty in middle-aged and elderly individuals.

ABSTRACT:

Background

In recent years, the increasing number of elderly individuals has highlighted frailty as a significant public health issue. Although the potential health benefits of bilirubin in adults are recognized, studies on the link between bilirubin levels and frailty are sparse. This study explores the association between serum total bilirubin (STB) and frailty in individuals aged 45-85 who participated in the National Health and Nutrition Examination Survey (NHANES) from 2015 to 2020.

Materials and methods

STB levels were measured using the Jendrassik-Grof method. Frailty was evaluated using a frailty index that included 49 deficits across seven domains. Survey weighted logistic regression analyses and Restricted Cubic Spline (RCS) techniques were used to examine the rela

SUBMITTER: Ling C 

PROVIDER: S-EPMC12279778 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature