MT2 receptor mediates melatonin-induced thermogenic program in human myoblasts: insights for circadian syndrome and diabesity treatment.

ABSTRACT:

Background

Melatonin is crucial for regulating circadian rhythms. Previous studies have demonstrated its ability to improve metabolic disorders, including obesity and associated diabetes (diabesity), in addition to its antioxidant, anti-inflammatory and anti-apoptotic properties. Recently, melatonin was shown to reduce obesity by increasing skeletal muscle (SKM) energy expenditure through non-shivering thermogenesis (NST). Small interfering RNAs (siRNAs) are powerful tools for inhibiting gene expression, enabling the analysis of gene functions and roles in molecular pathway activation. This study aimed to identify the receptor mediating melatonin's pharmacological actions in SKM NST.

Methods

Bioinformatics and protein-protein interaction (PPI) analyses were conducted. To exa

SUBMITTER: Salagre D 

PROVIDER: S-EPMC12279780 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature