Salivary gland transcriptomic analysis and immunophenotyping in the IL-14α transgenic mouse model of Sjogren's disease.

ABSTRACT: Sjögren's disease (SjD) is a systemic autoimmune disorder primarily affecting the exocrine glands and characterized by dry mouth and dry eye, the presence of anti-SSA and/or anti-SSB autoantibodies in blood serum, and chronic lymphocytic infiltration of salivary and lacrimal glands (i.e., sialadenitis and dacryoadenitis, respectively). In addition to reduced quality of life, SjD patients experience severe oral health complications and are at increased risk of developing B cell lymphoma. Because current SjD treatments primarily focus on oral and ocular symptom management, identifying initiating factors and mechanisms of disease progression may offer new therapeutic insights for SjD. The interleukin-14α transgenic (IL-14αTG) mouse model of SjD recapitulates many aspects of human SjD,

SUBMITTER: Woods LT 

PROVIDER: S-EPMC12279800 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature