Plasma protein biomarkers of <i>Plasmodium falciparum</i> infection in pregnant women: a high-throughput proteomics study.

ABSTRACT:

Introduction

Pregnant women in sub-Saharan Africa face heightened susceptibility to Plasmodium falciparum malaria, with placental sequestration driving adverse outcomes. The infection may lead to pregnancy-associated malaria (PAM) because of the sequestration of Plasmodium falciparum-infected erythrocytes in the placental intervillous space. Although there are several tools for diagnosing malaria infection during pregnancy, including blood smear microscopic examination, rapid diagnostic tests, and PCR, there are no tools for detecting placental infection and, by extension, any dysfunction associated with PAM. Thus, PAM, specifically placental infection, can only be confirmed via postnatal placental histopathology. Therefore, there is an urgent need for specific plasma

SUBMITTER: Kanoi BN 

PROVIDER: S-EPMC12279802 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature