Asymmetric neuromodulation in the respiratory network contributes to rhythm and pattern generation.

ABSTRACT: Like other brain circuits, the brainstem respiratory network is continually modulated by neurotransmitters that activate slow metabotropic receptors. In many cases, activation of these receptors only subtly modulates the respiratory motor pattern. However, activation of some receptor types evokes the arrest of the respiratory motor pattern as can occur following the activation of μ-opioid receptors. We propose that the varied effects of neuromodulation on the respiratory motor pattern depend on the pattern of neuromodulator receptor expression and their influence on the excitability of their post-synaptic targets. Because a comprehensive characterization of these cellular properties across the respiratory network remains challenging, we test our hypothesis by combining computational modeli

SUBMITTER: Dhingra RR 

PROVIDER: S-EPMC12279826 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature