Efficacy and safety of indigo naturalis oil extract (Lindioil ointment) for the treatment of atopic dermatitis: a randomized, crossover, evaluator-blinded, controlled trial.

ABSTRACT:

Introduction

Lindioil ointment or its compound formulations are commonly used traditional Chinese medicine practitioners to treat adult eczema or localized dermatitis. This study aimed to determine the efficacy and safety of Lindioil ointment (indigo naturalis oil extract) for treating atopic dermatitis (AD).

Methods

This was a prospective, randomized, crossover, evaluator-blinded, controlled study. Twenty-two patients with a median age of 26.5 (range, 20.8-44.3) years were treated with Lindioil or tacrolimus 0.1%. The primary outcome was change in the eczema areas severity index (EASI), body surface area (BSA), pruritus numeric rating scale (NRS) and dermatology life quality index (DLQI) after each 6-week treatment.

Results

After 6 weeks of treatment, the EASI decrea

SUBMITTER: Yang CY 

PROVIDER: S-EPMC12279832 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature