The comparison of remimazolam and midazolam in bronchoscopic sedation: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Effective sedation is critical for bronchoscopy, ensuring patient comfort and procedural success. Midazolam, though widely used, has limitations such as longer induction and recovery times. Remimazolam, a novel ultra-short-acting benzodiazepine, offers rapid onset, faster recovery, and a safer profile, making it a potential alternative.

Study design and methods

A systematic review and meta-analysis of four randomized controlled trials (RCTs) involving 630 patients compared remimazolam with midazolam for bronchoscopy sedation. Primary outcomes included induction time, recovery time, and rescue sedation rates. Secondary outcomes assessed procedural duration and adverse events. Random-effects models were used for analysis, and evidence quality was graded using GRADE

SUBMITTER: AbuJwaid YK 

PROVIDER: S-EPMC12279844 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature