Autoimmune polyglandular syndrome among Chinese celiac disease patients: a survey of 243 individuals in China.

ABSTRACT:

Background

Celiac disease (CeD), an autoimmune enteropathy, is often associated with multiple glandular autoimmune diseases. However, the prevalence and staging characteristics of autoimmune polyglandular syndrome (APS) among CeD patients remain unclear. The aim of this study was to assess the prevalence and clinical features of APS among Chinese CeD patients.

Methods

Clinical data and medical records of 243 CeD patients diagnosed in northwest China were retrospectively analyzed to identify comorbid autoimmune diseases among CeD patients. Serum interferon-ω1, interferon-α, and thyroid autoantibodies (TPOAb and TgAb) were measured, and AIRE mutations were detected. APS typing was conducted based on serum antibodies, gene sequencing (AIRE mutation analysis), and comorbidity an

SUBMITTER: Xue S 

PROVIDER: S-EPMC12279860 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature